Article
The regulated expression of an intrabody produces a mutant phenotype in Drosophila.
FEBS letters - 16 Oct 1998
Hassanzadeh Gh G, Devoogdt N, Ghysen A, De Baetselier P, Muyldermans S, Dambly-Chaudière C
Abstract excerpt
Intrabodies show great promise for controlling gene expression. As an initial attempt to evaluate the intrabody technology in Drosophila, the gene poxn was used as target. Transgenic flies harboring different anti-Poxn scFv genes integrated into various chromosomes were obtained. In one transformant, a phenocopy resembling the hypomorphic poxn-phenotype was produced in embryos and larvae following induction of...
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