Article
The regulated expression of an intrabody produces a mutant phenotype in Drosophila.
FEBS letters - 16 Oct 1998
Hassanzadeh Gh G, Devoogdt N, Ghysen A, De Baetselier P, Muyldermans S, Dambly-Chaudière C
Abstract excerpt
Intrabodies show great promise for controlling gene expression. As an initial attempt to evaluate the intrabody technology in Drosophila, the gene poxn was used as target. Transgenic flies harboring different anti-Poxn scFv genes integrated into various chromosomes were obtained. In one transform...
Topics
- Animals
- Animals, Genetically Modified
- DNA, Antisense
- Drosophila
- Drosophila Proteins
- Gene Expression Regulation
- Hot Temperature
- Immunoglobulin Fragments
- Mutation
- Nerve Tissue Proteins
- Paired Box Transcription Factors
- Phenotype
- Transcription Factors
- Transfection