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Article

Functional inhibition of transitory proteins by intrabody-mediated retention in the endoplasmatic reticulum.

Methods (San Diego, Calif.) - 1 Mar 2012

Böldicke Thomas, Somplatzki Stefan, Sergeev Galina, Mueller Peter P

Abstract excerpt

Intrabodies are recombinantly expressed intracellular antibody fragments that can be used to specifically bind and inhibit the function of cellular proteins of interest. Intrabodies can be targeted to various cell compartments by attaching an appropriate localization peptide sequence to them. An efficient strategy with a high success rate is to anchor intrabodies in the endoplasmatic reticulum where they can...

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Identifiers

PMID: 22037249
DOI: 10.1016/j.ymeth.2011.10.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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