Mutations in T cell receptor zeta chain mRNA of peripheral T cells from systemic lupus erythematosus patients.

Abstract excerpt

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown aetiology. Although it has been reported that T cells might be responsible for the pathogenesis of SLE, it remains unclear whether immune aberrations of SLE T cells are the primary event in this pathological process. W...

Topics

• Amino Acid Substitution
• Base Sequence
• Case-Control Studies
• DNA Primers
• DNA, Complementary
• Humans
• Lupus Erythematosus, Systemic
• Membrane Proteins
• Mutation
• Polymorphism, Single-Stranded Conformational
• RNA, Messenger
• Receptors, Antigen, T-Cell
• Reverse Transcriptase Polymerase Chain Reaction
• T-Lymphocytes