Article
Single-nucleotide polymorphisms of T cell receptor zeta chain in patients with systemic lupus erythematosus.
Arthritis and rheumatism - 1 Dec 1999
Wu J, Edberg J C, Gibson A W, Tsao B, Kimberly R P
Abstract excerpt
OBJECTIVE: Signaling molecules from the T cell receptor zeta/Fcepsilon receptor gamma (TCRzeta/FcRgamma) family play a critical role in the function of Fcgamma receptors and the TCR and are located on human chromosome 1, where lupus susceptibility genes are located. This study was undertaken to investigate the possibility of polymorphisms and/or mutations of TCRzeta in systemic lupus erythematosus (SLE). METHODS:...
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