Article
Linkage analysis between bipolar affective disorder and markers on chromosome X.
Psychiatric genetics - 1 Jan 1998
Vallada H P, Vasques L, Curtis D, Zatz M, Kirov G, Lauriano V, Gentil V, Murray R M, McGuffin P, Owen M, Gill M, Craddock N, Collier D A
Abstract excerpt
Since 1969, several classical linkage studies suggested an X-chromosome locus for bipolar affective disorder. However, methods using highly polymorphic DNA markers have provided conflicting evidence for linkage, and an X-chromosomal locus for bipolar disorder remains controversial. More recently, Pekkarinen et al. (1995) found a maximum LOD score of 3.54 at the marker DXS994 in a large bipolar Finnish kindred. In...
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