Article
Active ERK2 is sufficient to mediate growth arrest and differentiation signaling.
The FEBS journal - 1 Mar 2015
Wu Pui-Kei, Hong Seung-Keun, Yoon Seung-Hee, Park Jong-In
Abstract excerpt
Although extracellular signal-regulated kinases (ERK1/2) have been shown to be required in Raf/MEK/ERK pathway signaling, its sufficiency for mediating the pathway signaling has not been firmly established. In an effort to address this, we evaluated previously described ERK2 mutants that exhibit enhanced autophosphorylation of TEY sites in the activation loop in terms of their ability to induce growth arrest and...
Topics
- Animals
- Binding Sites
- Cell Cycle
- Cell Differentiation
- Cell Line, Tumor
- Cell Proliferation
- Cellular Senescence
- HEK293 Cells
- Humans
- MAP Kinase Signaling System
- Male
- Mutation
- PC12 Cells
- Phosphorylation
- Plasmids
- Protein Structure, Tertiary
- Rats
- Receptors, Androgen