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Article

Active ERK2 is sufficient to mediate growth arrest and differentiation signaling.

The FEBS journal - 1 Mar 2015

Wu Pui-Kei, Hong Seung-Keun, Yoon Seung-Hee, Park Jong-In

Abstract excerpt

Although extracellular signal-regulated kinases (ERK1/2) have been shown to be required in Raf/MEK/ERK pathway signaling, its sufficiency for mediating the pathway signaling has not been firmly established. In an effort to address this, we evaluated previously described ERK2 mutants that exhibit enhanced autophosphorylation of TEY sites in the activation loop in terms of their ability to induce growth arrest and...

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Identifiers

PMID: 25639353
DOI: 10.1111/febs.13197
PMCID: PMC4368470

Genes

ELK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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