Article
DNA methylation differences associated with tumor tissues identified by genome scanning analysis.
Genomics - 1 Nov 1998
Liang G, Salem C E, Yu M C, Nguyen H D, Gonzales F A, Nguyen T T, Nichols P W, Jones P A
Abstract excerpt
Most investigations on the role of DNA methylation in cancer have focused on epigenetic changes associated with known tumor suppressor genes. This may have led to an underestimation of the number of CpG islands altered by DNA methylation, since it is possible that a subset of unknown genes releva...
Topics
- Base Sequence
- Colonic Neoplasms
- CpG Islands
- DNA Methylation
- DNA Primers
- DNA, Neoplasm
- Genes, Tumor Suppressor
- Genome, Human
- Humans
- Leukocytes
- Male
- Neoplasms
- Phenotype
- Polymerase Chain Reaction
- Promoter Regions, Genetic
- Prostatic Neoplasms
- Transcription, Genetic
- Urinary Bladder Neoplasms