Extensive intra- and interindividual heterogeneity of p15INK4B methylation in acute myeloid leukemia.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Extensive intra- and interindividual heterogeneity of p15INK4B methylation in acute myeloid leukemia.

Cancer research - 15 Jan 1999

Aggerholm A, Guldberg P, Hokland M, Hokland P

Abstract excerpt

Silencing of the cyclin-dependent kinase inhibitor gene p15INK4B by cytosine methylation of the promoter region has been associated with some types of hematological malignancy. To study in detail the patterns of p15INK4B methylation in patients with acute myeloid leukemia, we adopted a novel appr...

Topics

Alleles
Base Sequence
Cell Cycle Proteins
Cyclin-Dependent Kinase Inhibitor p15
DNA Methylation
Humans
Leukemia, Myeloid, Acute
Leukocytes, Mononuclear
Molecular Sequence Data
Polymerase Chain Reaction
Promoter Regions, Genetic
Transcription Factors
Tumor Suppressor Proteins

Source

Open in PubMed

Identifiers

PMID: 9927059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9927059-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics