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Article

Characterization of functional regions in the Schizosaccharomyces pombe mei3 developmental activator.

Genetics - 1 Nov 1998

Wang W, Li P, Schettino A, Peng Z, McLeod M

Abstract excerpt

The Schizosaccharomyces pombe mei3(+) gene is expressed only in diploid cells undergoing meiosis. Ectopic expression of mei3(+) in haploid cells causes meiotic catastrophe. Mei3 is an inhibitor of Ran1/Pat1 kinase and contains a nine-amino-acid motif, Mei3-RKDIII, that resembles two regions in the Ste11 substrate for Ran1/Pat1. Substitution of serine for Arg-81 within Mei3-RKDIII transforms the inhibitor into a...

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Identifiers

PMID: 9799254
DOI: 10.1093/genetics/150.3.1007
PMCID: PMC1460408

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