Inherent DNA curvature and flexibility correlate with TATA box functionality.

doi:10.1002/(SICI)1097-0282(199811)46:6<403::AID-BIP5>3.0.CO;2-A

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Article

Inherent DNA curvature and flexibility correlate with TATA box functionality.

Biopolymers - 1 Nov 1998

de Souza O N, Ornstein R L

Abstract excerpt

Four 1.5 ns molecular dynamics (MD) simulations were performed on the d(GCTATAAAAGGG).d(CCCTTTTATAGC) double helix dodecamer bearing the Adenovirus major late promoter TATA element and three iso-composition mutants for which physical and biochemical data are available from the same laboratory. Th...

Topics

Adenoviridae
Base Pairing
DNA, Viral
DNA-Binding Proteins
Mutation
Nucleic Acid Conformation
Promoter Regions, Genetic
TATA Box
TATA-Box Binding Protein
Transcription Factors
Transcription, Genetic
X-Ray Diffraction

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