Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inherent DNA curvature and flexibility correlate with TATA box functionality.

Biopolymers - 1 Nov 1998

de Souza O N, Ornstein R L

Abstract excerpt

Four 1.5 ns molecular dynamics (MD) simulations were performed on the d(GCTATAAAAGGG).d(CCCTTTTATAGC) double helix dodecamer bearing the Adenovirus major late promoter TATA element and three iso-composition mutants for which physical and biochemical data are available from the same laboratory. Three of these DNA sequences experimentally induce tight binding with the TATA box binding protein (TBP) and induce high...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to DNA, Viral
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Nucleic Acid Conformation

Share to Promoter Regions, Genetic

Share to TATA Box

Share to Transcription Factors

Share to Transcription, Genetic

Source

Identifiers

PMID: 9798428
DOI: 10.1002/(SICI)1097-0282(199811)46:6<403::AID-BIP5>3.0.CO;2-A

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inherent DNA curvature and flexibility correlate with TATA box functionality.PMID 9798428Read ↗

Dynamic simulations of 13 TATA variants refine kinetic hypotheses of sequence/activity relationships.Semantic proximity Read ↗

Sequence-dependent solution structure and motions of 13 TATA/TBP (TATA-box binding protein) complexes.Semantic proximity Read ↗

DNA bending is an important component of site-specific recognition by the TATA binding protein.Semantic proximity Read ↗

TFIIA changes the conformation of the DNA in TBP/TATA complexes and increases their kinetic stability.Semantic proximity Read ↗

DNA sequence-specific recognition by a transcriptional regulator requires indirect readout of A-tracts.Semantic proximity Read ↗

Signals for TBP/TATA box recognition.Semantic proximity Read ↗

Solid-to-fluid–like DNA transition in viruses facilitates infectionSemantic proximity Read ↗

Protein flexibility directs DNA recognition by the papillomavirus E2 proteins.Semantic proximity Read ↗

Structural basis of protein stability and DNA-protein interaction.Semantic proximity Read ↗

Ionic switch controls the DNA state in phage λSemantic proximity Read ↗

Structural requirements for trans activation of human immunodeficiency virus type 1 long terminal repeat-directed gene expression by tat: importance of base pairing, loop sequence, and bulges in the tat-responsive sequence.Semantic proximity Read ↗

Identification of amino acids that promote specific and rigid TAR RNA-tat protein complex formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.