Article
Protein flexibility directs DNA recognition by the papillomavirus E2 proteins.
Nucleic acids research - 1 Apr 2011
Brown Craig, Campos-León Karen, Strickland Madeleine, Williams Christopher, Fairweather Victoria, Brady R Leo, Crump Matthew P, Gaston Kevin
Abstract excerpt
Although DNA flexibility is known to play an important role in DNA-protein interactions, the importance of protein flexibility is less well understood. Here, we show that protein dynamics are important in DNA recognition using the well-characterized human papillomavirus (HPV) type 6 E2 protein as a model system. We have compared the DNA binding properties of the HPV 6 E2 DNA binding domain (DBD) and a mutant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.