Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway.

Frontiers in cellular and infection microbiology - 1 Jan 2017

Gunawardhana Niluka, Jang Sungil, Choi Yun Hui, Hong Youngmin A, Jeon Yeong-Eui, Kim Aeryun, Su Hanfu, Kim Ji-Hye, Yoo Yun-Jung, Merrell D Scott, Kim Jinmoon, Cha Jeong-Heon

Abstract excerpt

Helicobacter pylori is associated with hypergastrinemia, which has been linked to the development of gastric diseases. Although the molecular mechanism is not fully understood, H. pylori is known to modulate the Erk pathway for induction of gastrin expression. Herein we found that an epidermal growth factor (EGF) receptor kinase inhibitor significantly blocked H. pylori-induced gastrin promoter activity,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ErbB Receptors
Share to Gastrins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Reporter

Share to Helicobacter Infections

Share to Helicobacter pylori

Share to Heparin-binding EGF-like Growth Factor

Share to Mitogen-Activated Protein Kinase 1

Share to Proto-Oncogene Proteins c-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 29379775
DOI: 10.3389/fcimb.2017.00541
PMCID: PMC5775237

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway.PMID 29379775Read ↗

Helicobacter pylori promotes gastric fibroblast proliferation and migration by expulsing exosomal miR-124-3pSemantic proximity Read ↗

Gastrin induces parathyroid hormone-like hormone expression in gastric parietal cells.Semantic proximity Read ↗

FGF signaling network in the gastrointestinal tract (Review)Semantic proximity Read ↗

Evaluation of the effect of Helicobacter pylori -derived OMVs and released exosomes from stomach cells treated with OMVs on the expression of genes related to the TGF-β/SMAD signaling pathway in hepatocellular carcinomaSemantic proximity Read ↗

Helicobacter pylori promotes gastric cancer progression by upregulating semaphorin 5A expression via ERK/MMP9 signalingSemantic proximity Read ↗

A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans.Semantic proximity Read ↗

Hedgehog signaling pathway and gastric cancerSemantic proximity Read ↗

Helicobacter pylori modulates host cell survival regulation through the serine-threonine kinase, 3-phosphoinositide dependent kinase 1 (PDK-1)Semantic proximity Read ↗

<i>Helicobacter pylori</i>stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factorsSemantic proximity Read ↗

Role of ERK activation in <i>H. pylori</i> -induced disruption of cell-cell tight junctionsSemantic proximity Read ↗

Transactivation of the epidermal growth factor receptor by cag+ Helicobacter pylori induces upregulation of the early growth response gene Egr-1 in gastric epithelial cellsSemantic proximity Read ↗

Suppression of growth and migration by blocking the hedgehog signaling pathway in gastric cancer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.