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Synthesis of gatifloxacin derivatives and their biological activities against Mycobacterium leprae and Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry - 15 Feb 2013

Gomez Catherine, Ponien Prishila, Serradji Nawal, Lamouri Aazdine, Pantel Alix, Capton Estelle, Jarlier Vincent, Anquetin Guillaume, Aubry Alexandra

Abstract excerpt

Novel 3'-piperazinyl derivatives of the 8-hydrogeno and 8-methoxy-6-fluoro-1-cyclopropyl-4-quinolone-3-carboxylic acid scaffolds were designed, synthesized and characterized by (1)H, (13)C and (19)F NMR, and HRMS. The activity of these derivatives against pathogenic mycobacteria (M. leprae and M. tuberculosis), wild-type (WT) strains or strains harboring mutations implicated in quinolone resistance, were...

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PMID: 23294829
DOI: 10.1016/j.bmc.2012.12.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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