Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mekk3 is essential for early embryonic cardiovascular development.

Nature genetics - 1 Mar 2000

Yang J, Boerm M, McCarty M, Bucana C, Fidler I J, Zhuang Y, Su B

Abstract excerpt

The early development of blood vessels consists of two phases, vasculogenesis and angiogenesis, which involve distinct and also overlapping molecular regulators, but the intracellular signal transduction pathways involved in these processes have not been well defined. We disrupted Map3k3 (also known as Mekk3), which encodes Mekk3, a member of the Mekk/Ste11 family, in mice. Map3k3-/- embryos died at approximately...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Vessels
Share to Embryonic and Fetal Development
Share to Fetal Heart

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fetal Proteins

Share to Gestational Age

Share to MAP Kinase Kinase Kinases

Share to Neovascularization, Physiologic

Share to Yolk Sac

Source

Identifiers

PMID: 10700190
DOI: 10.1038/73550

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mekk3 is essential for early embryonic cardiovascular development.PMID 10700190Read ↗

Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3Semantic proximity Read ↗

LKB1 in endothelial cells is required for angiogenesis and TGFβ-mediated vascular smooth muscle cell recruitmentSemantic proximity Read ↗

Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos.Semantic proximity Read ↗

A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos.Semantic proximity Read ↗

Essential Roles of Exocyst Complex Component 3-like 2 on Cardiovascular Development in MiceSemantic proximity Read ↗

MEKK3-TGFβ crosstalk regulates inward arterial remodelingSemantic proximity Read ↗

Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and FunctionSemantic proximity Read ↗

Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development.Semantic proximity Read ↗

Functions of MAP kinases: insights from gene-targeting studies.Semantic proximity Read ↗

Endothelial cell expression of mutant Map2k1 causes vascular malformations in mice.Semantic proximity Read ↗

MEKK3-TGFβ crosstalk regulates inward arterial remodeling.Semantic proximity Read ↗

Zebrafish mutants in vegfab can affect endothelial cell proliferation without altering ERK phosphorylation and are phenocopied by loss of PI3K signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.