Article
Efficacy of methuselah gene mutation toward tolerance of dichlorvos exposure in Drosophila melanogaster.
Free radical biology & medicine - 1 Jun 2015
Pandey Ashutosh, Khatoon Rehana, Saini Sanjay, Vimal Divya, Patel Devendra Kumar, Narayan Gopeshwar, Chowdhuri Debapratim Kar
Abstract excerpt
Adverse reports on the exposure of organisms to dichlorvos (DDVP; an organophosphate insecticide) necessitate studies of organismal resistance/tolerance by way of pharmacological or genetic means. In the context of genetic modulation, a mutation in methuselah (mth; encodes a class II G-protein-coupled receptor (GPCR)) is reported to extend (~35%) the life span of Drosophila melanogaster and enhance their...
Topics
- Animals
- Animals, Genetically Modified
- Anthelmintics
- Antioxidants
- Apoptosis
- Blotting, Western
- Cell Proliferation
- Dichlorvos
- Drosophila Proteins
- Drosophila melanogaster