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Efficacy of methuselah gene mutation toward tolerance of dichlorvos exposure in Drosophila melanogaster.

Free radical biology & medicine - 1 Jun 2015

Pandey Ashutosh, Khatoon Rehana, Saini Sanjay, Vimal Divya, Patel Devendra Kumar, Narayan Gopeshwar, Chowdhuri Debapratim Kar

Abstract excerpt

Adverse reports on the exposure of organisms to dichlorvos (DDVP; an organophosphate insecticide) necessitate studies of organismal resistance/tolerance by way of pharmacological or genetic means. In the context of genetic modulation, a mutation in methuselah (mth; encodes a class II G-protein-coupled receptor (GPCR)) is reported to extend (~35%) the life span of Drosophila melanogaster and enhance their...

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PMID: 25746179
DOI: 10.1016/j.freeradbiomed.2015.02.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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