Dendritic cell immunization breaks cytotoxic T lymphocyte tolerance in hepatitis B virus transgenic mice.

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Article

Dendritic cell immunization breaks cytotoxic T lymphocyte tolerance in hepatitis B virus transgenic mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1998

Shimizu Y, Guidotti L G, Fowler P, Chisari F V

Abstract excerpt

Hepatitis B virus (HBV) transgenic mice that are immunologically tolerant to HBV-encoded Ags represent a model of chronic HBV infection suitable for the development of therapeutic immunization strategies before testing in humans. Five lineages of HBV transgenic mice were immunized with plasmid DN...

Topics

Adoptive Transfer
Animals
Bone Marrow Cells
DNA, Recombinant
Dendritic Cells
Hepatitis B Surface Antigens
Hepatitis B Vaccines
Hepatitis B e Antigens
Hepatitis B virus
Immune Tolerance
Immunization
Liver
Mice
Mice, Inbred C57BL
Mice, Transgenic
Phenotype
RNA, Viral
Spleen

Source

Open in PubMed

Identifiers

PMID: 9794377

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9794377-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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