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Article

Effect of the MTHFRC677T variant on risk of venous thromboembolism: interaction with factor V Leiden and prothrombin (F2G20210A) mutations.

British journal of haematology - 1 Oct 1998

Brown K, Luddington R, Baglin T

Abstract excerpt

Odds ratios for the MTHFRC677T variant were determined in a large case-control study of 558 unselected patients with venous thromboembolism and 500 control subjects. The odds ratios for MTHFRC677T heterozygosity and homozygosity were 1.07 (95%CI 0.84-1.36) and 0.71 (95%CI 0.48-1.03). In patients...

Topics

Adolescent
Adult
Aged
Child
Factor V
Heterozygote
Homozygote
Humans
Methylenetetrahydrofolate Reductase (NADPH2)
Middle Aged
Mutation
Oxidoreductases Acting on CH-NH Group Donors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prothrombin

Risk Factors

Thromboembolism

Source

Identifiers

PMID: 9792287
DOI: 10.1046/j.1365-2141.1998.00935.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9792287-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Effect of the MTHFRC677T variant on risk of venous thromboembolism: interaction with factor V Leiden and prothrombin (F2G20210A) mutations.PMID 9792287Read ↗

Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls.Semantic proximity Read ↗

THROMBOTIC RISK EVALUATION OF TWO METHYLENETETRAHYDROFOLATE REDUCTASE MUTATIONS C677t AND A1298c IN VENOUS THROMBOEMBOLISM.Semantic proximity Read ↗

Prothrombin 20210 G-->A, MTHFR C677T mutations in women with venous thromboembolism associated with pregnancy.Semantic proximity Read ↗

The risk of venous thromboembolism in family members with mutations in the genes of factor V or prothrombin or both.Semantic proximity Read ↗

Coexistence of the methylenetetrahydrofolate reductase single-nucleotide polymorphism (C677T) in patients with the factor V Leiden or prothrombin G20210A polymorphisms.Semantic proximity Read ↗

No interaction between factor V Leiden and hyperhomocysteinemia or MTHFR 677TT genotype in venous thrombosis. Results of a meta-analysis of published studies and a large case-only study.Semantic proximity Read ↗

Prothrombin A19911G polymorphism and the risk of venous thromboembolism.Semantic proximity Read ↗

Do thrombophilic gene mutations have a role on thromboembolic events in cancer patients?Semantic proximity Read ↗

The methylenetetrahydrofolate reductase TT677 genotype is associated with venous thrombosis independently of the coexistence of the FV Leiden and the prothrombin A20210 mutation.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T genotype and venous thromboembolic disease.Semantic proximity Read ↗

Major and potential prothrombotic genotypes in a cohort of patients with venous thromboembolism.Semantic proximity Read ↗

Common C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of venous thromboembolism: meta-analysis of 31 studies.Semantic proximity Read ↗

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