Article
Common C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of venous thromboembolism: meta-analysis of 31 studies.
Pathophysiology of haemostasis and thrombosis - 1 Jan 2000
Ray J G, Shmorgun D, Chan W S
Abstract excerpt
BACKGROUND: Although the common 677 C --> T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene is implicated in the development of hyperhomocysteinemia, its correlation with venous thromboembolism (VTE) remains controversial. We conducted a meta-analysis of previously published...
Topics
- Adult
- Case-Control Studies
- Databases, Factual
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Homozygote
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Odds Ratio
- Oxidoreductases Acting on CH-NH Group Donors
- Polymorphism, Single Nucleotide
- Risk
- Thromboembolism
- Venous Thrombosis