Article
No interaction between factor V Leiden and hyperhomocysteinemia or MTHFR 677TT genotype in venous thrombosis. Results of a meta-analysis of published studies and a large case-only study.
Thrombosis and haemostasis - 1 Jan 2007
Keijzer Miranda B A J, Borm George F, Blom Henk J, Bos Gerard M J, Rosendaal Frits R, den Heijer Martin
Abstract excerpt
Homocysteine may have a thrombogenic effect through inhibition of inactivation of factor Va by activated protein C. Because factor V Leiden also leads to resistance of factor V to activated protein C, it would be possible that both factors show interaction for the risk of venous thrombosis. This has been reported in some studies, but not in others. We performed a metaanalysis to investigate a possible interaction...
Topics
- Factor V
- Genotype
- Humans
- Hyperhomocysteinemia
- Methylenetetrahydrofolate Reductase (NADPH2)
- Odds Ratio
- Risk
- Venous Thrombosis