Article
The risk of venous thromboembolism in family members with mutations in the genes of factor V or prothrombin or both.
British journal of haematology - 1 Dec 2000
Martinelli I, Bucciarelli P, Margaglione M, De Stefano V, Castaman G, Mannucci P M
Abstract excerpt
Factor V Leiden and the G20210A mutation in the prothrombin gene are the most frequent abnormalities associated with venous thromboembolism. It is unknown whether the risks due to the presence of either mutation are of the same magnitude. We compared the prevalence and incidence rate of venous thromboembolism in relatives with either mutation or both. The finding of different rates might influence the strategies...
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