Article
Risk of venous thromboembolism associated with single and combined effects of Factor V Leiden, Prothrombin 20210A and Methylenetethraydrofolate reductase C677T: a meta-analysis involving over 11,000 cases and 21,000 controls.
European journal of epidemiology - 1 Aug 2013
Simone Benedetto, De Stefano Valerio, Leoncini Emanuele, Zacho Jeppe, Martinelli Ida, Emmerich Joseph, Rossi Elena, Folsom Aaron R, Almawi Wassim Y, Scarabin Pierre Y, den Heijer Martin, Cushman Mary, Penco Silvana, Vaya Amparo, Angchaisuksiri Pantep, Okumus Gulfer, Gemmati Donato, Cima Simona, Akar Nejat, Oguzulgen Kivilcim I, Ducros Véronique, Lichy Christoph, Fernandez-Miranda Consuelo, Szczeklik Andrzej, Nieto José A, Torres Jose Domingo, Le Cam-Duchez Véronique, Ivanov Petar, Cantu-Brito Carlos, Shmeleva Veronika M, Stegnar Mojka, Ogunyemi Dotun, Eid Suhair S, Nicolotti Nicola, De Feo Emma, Ricciardi Walter, Boccia Stefania
Abstract excerpt
Genetic and environmental factors interact in determining the risk of venous thromboembolism (VTE). The risk associated with the polymorphic variants G1691A of factor V (Factor V Leiden, FVL), G20210A of prothrombin (PT20210A) and C677T of methylentetrahydrofolate reductase (C677T MTHFR) genes has been investigated in many studies. We performed a pooled analysis of case-control and cohort studies investigating in...
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