Article
Mutations at sites involved in Suc1 binding inactivate Cdc2.
Molecular and cellular biology - 1 Dec 1991
Ducommun B, Brambilla P, Draetta G
Abstract excerpt
suc1+ encodes an essential cell cycle regulator of the fission yeast Schizosaccharomyces pombe. Its product, a 13-kDa protein, interacts with the Cdc2 protein kinase. Both positive and negative effects on cell cycle progression have been attributed to Suc1. To date, the exact mechanisms and the physiological role of the interaction between Suc1 and Cdc2 remain unclear. Here we have studied the molecular basis of...
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