Article
Association of CYP3A4 genotype with detection of Vgamma/Jbeta trans-rearrangements in the peripheral blood leukocytes of pediatric cancer patients undergoing chemotherapy for ALL.
Leukemia research - 1 Dec 2004
Lopes Luiz Fernando, Piccoli Fábio De Simone, Paixão Valéria A, Latorre Maria do Rosário D O, Camargo Beatriz de, Simpson Andrew J G, Caballero Otávia L
Abstract excerpt
Cancer patients receiving chemotherapy are exposed to high doses of cytotoxic and genotoxic drugs which, in some cases, can lead to treatment related leukemia. Since this only occurs in a minority of patients, however, it is possible some individuals are predisposed due to genetic polymorphisms in genes for enzymes that mediate drug metabolism. To address this possibility we measured the genotoxicity of...
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