Article
Effect of D57N mutation on membrane activity and molecular unfolding of cobra cardiotoxin.
Biophysical journal - 1 Nov 1998
Lo C C, Hsu J H, Sheu Y C, Chiang C M, Wu W g, Fann W, Tsao P H
Abstract excerpt
Cobra cardiotoxins (CTXs) are able to adopt a three-fingered beta-strand structure with continuous hydrophobic patch that is capable of interacting with zwitterionic phospholipid bilayer. In addition to the four disulfide bonds that form the rigid core of CTXs, Asp57 near the C-terminus interacts...
Topics
- Anilino Naphthalenesulfonates
- Animals
- Circular Dichroism
- Cobra Cardiotoxin Proteins
- Fluorescent Dyes
- Models, Molecular
- Mutation
- Polytetrafluoroethylene
- Protein Folding
- Protein Structure, Secondary
- Spectrometry, Fluorescence
- Sphingomyelins
- Static Electricity
- Tryptophan