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Article

The effect of core destabilization on the mechanical resistance of I27.

Biophysical journal - 1 Jul 2002

Brockwell David J, Beddard Godfrey S, Clarkson John, Zinober Rebecca C, Blake Anthony W, Trinick John, Olmsted Peter D, Smith D Alastair, Radford Sheena E

Abstract excerpt

It is still unclear whether mechanical unfolding probes the same pathways as chemical denaturation. To address this point, we have constructed a concatamer of five mutant I27 domains (denoted (I27)(5)*) and used it for mechanical unfolding studies. This protein consists of four copies of the muta...

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Identifiers

PMID: 12080133
DOI: 10.1016/S0006-3495(02)75182-5
PMCID: PMC1302160

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12080133-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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