Article
Neisseria gonorrhoeae heme biosynthetic mutants utilize heme and hemoglobin as a heme source but fail to grow within epithelial cells.
Infection and immunity - 1 Nov 1998
Turner P C, Thomas C E, Elkins C, Clary S, Sparling P F
Abstract excerpt
Many bacterial pathogens, including pathogenic neisseriae, can use heme as an iron source for growth. To study heme utilization by Neisseria gonorrhoeae, two heme biosynthetic mutants were constructed, one with a mutation in hemH (the gene encoding ferrochelatase) and one with a mutation in hemA...
Topics
- Aldehyde Oxidoreductases
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Carrier Proteins
- Cell Line
- Cervix Uteri
- Epithelial Cells
- Female
- Heme
- Hemoglobins
- Humans
- Intracellular Fluid
- Iron
- Iron-Binding Proteins
- Mutagenesis, Site-Directed