Investigating the importance of selected surface-exposed loops in HpuB for hemoglobin binding and utilization by Neisseria gonorrhoeae.

doi:10.1128/iai.00211-24

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Article

Investigating the importance of selected surface-exposed loops in HpuB for hemoglobin binding and utilization by Neisseria gonorrhoeae.

Infection and immunity - 11 Jul 2024

Awate Olivia A, Ng Dixon, Stoudenmire Julie L, Moraes Trevor F, Cornelissen Cynthia N

Abstract excerpt

Neisseria gonorrhoeae is the etiological agent of the sexually transmitted infection gonorrhea. The pathogen is a global health challenge since no protective immunity results from infection, and far fewer treatment options are available with increasing antimicrobial resistance. With no efficacious vaccines, researchers are exploring new targets for vaccine development and innovative therapeutics. The outer...

Topics

Neisseria gonorrhoeae
Hemoglobins
Bacterial Proteins
Protein Binding
Iron
Mutation
Gonorrhea
Bacterial Outer Membrane Proteins
Animals
Humans
Carrier Proteins

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Identifiers

PMID: 38864605
DOI: 10.1128/iai.00211-24
PMCID: PMC11238557

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