Article
Characterization of ferrochelatase (hemH) mutations in Haemophilus influenzae.
Infection and immunity - 1 May 2000
Schlör S, Herbert M, Rodenburg M, Blass J, Reidl J
Abstract excerpt
Haemophilus influenzae lacks most of the biosynthetic enzymes for hemin synthesis. However, the organism has retained ferrochelatase activity, which we identified to be encoded by a hemH-homologous gene. In this report we characterize the growth physiology conferred by hemH mutations under infection and laboratory conditions.
Topics
- Animals
- Ferrochelatase
- Haemophilus influenzae
- Mutagenesis
- Phenotype
- Rats
- Rats, Sprague-Dawley