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Article

Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas.

The Laryngoscope - 1 Oct 1998

Henderson Y C, Wang E, Clayman G L

Abstract excerpt

OBJECTIVES: Tumor suppressor gene mutations in both p53 and PTEN/MMAC1 genomic DNA have been detected in many types of cancer. The purpose of this study was to investigate the presence and importance of PTEN/MMAC1 mutations in squamous cell carcinomas. METHODS: Exons of each gene were amplified after polymerase chain reaction (PCR) using genomic DNA derived from cell lines of squamous cell carcinoma of the head...

Read the complete abstract on PubMed

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Share to DNA, Neoplasm
Share to Genes, p53
Share to Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Point Mutation

Share to Polymerase Chain Reaction

Share to Sequence Analysis, DNA

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 9778300
DOI: 10.1097/00005537-199810000-00024

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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