Article
Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas.
The Laryngoscope - 1 Oct 1998
Henderson Y C, Wang E, Clayman G L
Abstract excerpt
OBJECTIVES: Tumor suppressor gene mutations in both p53 and PTEN/MMAC1 genomic DNA have been detected in many types of cancer. The purpose of this study was to investigate the presence and importance of PTEN/MMAC1 mutations in squamous cell carcinomas. METHODS: Exons of each gene were amplified a...
Topics
- Carcinoma, Squamous Cell
- DNA, Neoplasm
- Genes, Tumor Suppressor
- Genes, p53
- Genotype
- Head and Neck Neoplasms
- Humans
- PTEN Phosphohydrolase
- Phosphoric Monoester Hydrolases
- Point Mutation
- Polymerase Chain Reaction
- Protein Tyrosine Phosphatases
- Sequence Analysis, DNA
- Tumor Cells, Cultured
- Tumor Suppressor Proteins