Article
Lack of association between polymorphism of the thyrotropin receptor gene and Graves' disease in United Kingdom and Hong Kong Chinese patients: case control and family-based studies.
Thyroid : official journal of the American Thyroid Association - 1 Sept 1998
Allahabadia A, Heward J M, Mijovic C, Carr-Smith J, Daykin J, Cockram C, Barnett A H, Sheppard M C, Franklyn J A, Gough S C
Abstract excerpt
The thyrotropin receptor (TSH-R) gene is a candidate for genetic susceptibility to Graves' disease (GD). Previous case control studies investigating allelic association of a polymorphism at position 253 (C253 to A253) of the TSH-R gene have shown conflicting results. We genotyped two independent case control datasets (UK Caucasian and Hong Kong Chinese), for the A253 polymorphism. The Transmission Disequilibrium...
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