[A new inherited RET proto-oncogene mutation associated with familial medullary thyroid carcinoma and polymorphisms in adjacent regions].

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Article

[A new inherited RET proto-oncogene mutation associated with familial medullary thyroid carcinoma and polymorphisms in adjacent regions].

Genetika - 1 Aug 1998

Kalinin V N, Amosenko F A, Puskas C, Frilling A, Broelsch C E, Pushkash K, Brel'sh K E

Abstract excerpt

A new point mutation, TCG(Ser)-->GCG(Ala) in codon 891, exon 15 of the RET protooncogene was revealed in two patients from a pedigree with familial medullary thyroid carcinoma (FMTC), but not in healthy persons. A linkage analysis with two well-known and two new intragene polymorphisms showed tha...

Topics

Carcinoma, Medullary
Codon
Drosophila Proteins
Exons
Female
Genetic Linkage
Genetic Markers
Humans
Male
Pedigree
Phenotype
Point Mutation
Polymorphism, Genetic
Proto-Oncogene Mas
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-ret
Proto-Oncogenes
Receptor Protein-Tyrosine Kinases

Source

Open in PubMed

Identifiers

PMID: 9777362

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9777362-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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