Article
[Molecular diagnosis of multiple type 2 endocrine neoplasia].
Vestnik Rossiiskoi akademii meditsinskikh nauk - 1 Jan 2001
Amosenko F A, Pushkash K, Frilling A, Kozlova V N, Liubchenko L N, Kazubskaia T P, Brelysh K E, Gar'kavtseva R F, Kalinin V N
Abstract excerpt
The paper reviews the data on the molecular structure of the protooncogene RET encoding for receptor-type protein kinase, on the mechanism of transformation of the normal protooncogene RET to a dominant transforming oncogene, and on RET mutations detected in patients with the MEN-2 syndrome. Moreover, it presents the authors' own findings. The familial medullary thyroid carcinoma burdened genealogy shows a new...
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