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Article

A new hot spot for mutations in the ret protooncogene causing familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2A.

The Journal of clinical endocrinology and metabolism - 1 Mar 1998

Berndt I, Reuter M, Saller B, Frank-Raue K, Groth P, Grussendorf M, Raue F, Ritter M M, Höppner W

Abstract excerpt

One hundred and eighty-one families with multiple endocrine neoplasia type 2A (MEN-2A) or familial medullary thyroid carcinoma (FMTC) have been investigated for mutations in the ret protooncogene in Germany. In 8 families with FMTC or MEN-2A, no mutation could be detected in the cysteine-rich domain encoded in exons 10 and 11 of the ret protooncogene. DNA sequencing of additional exons (no. 13-15) revealed rare...

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PMID: 9506724
DOI: 10.1210/jcem.83.3.4619

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Related research

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A new hot spot for mutations in the ret protooncogene causing familial medullary thyroid carcinoma and multiple endocrine neoplasia type 2A.PMID 9506724Read ↗

A New Hot Spot for Mutations in the ret Protooncogene Causing Familial Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Type 2ASemantic proximity Read ↗

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Difference in development of medullary thyroid carcinoma among carriers of RET mutations in codons 790 and 791.Semantic proximity Read ↗

RET mutation Tyr791Phe: the genetic cause of different diseases derived from neural crest.Semantic proximity Read ↗

Change in the spectrum of RET mutations diagnosed between 1994 and 2006.Semantic proximity Read ↗

Presence of the RET Cys634Tyr mutation and Gly691Ser functional polymorphism in Iranian families with multiple endocrine neoplasia type 2A.Semantic proximity Read ↗

Mutation of RET codon 768 is associated with the FMTC phenotype.Semantic proximity Read ↗

Mutations of the ret protooncogene in German multiple endocrine neoplasia families: relation between genotype and phenotype. German Medullary Thyroid Carcinoma Study Group.Semantic proximity Read ↗

[Management of multiple endocrine neoplasia syndrome type 2 families in association with rare germline mutations of the RET proto-oncogene].Semantic proximity Read ↗

RET proto-oncogene mutations are restricted to codons 634 and 918 in mainland Chinese families with MEN2A and MEN2B.Semantic proximity Read ↗

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