Article
Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity.
The Biochemical journal - 1 Sept 2007
Li Jun, Tumanut Christine, Gavigan Julie-Ann, Huang Waan-Jeng, Hampton Eric N, Tumanut Rachelle, Suen Ka Fai, Trauger John W, Spraggon Glen, Lesley Scott A, Liau Gene, Yowe David, Harris Jennifer L
Abstract excerpt
PCSK9 (proprotein convertase subtilisin/kexin 9) is a secreted serine protease that regulates cholesterol homoeostasis by inducing post-translational degradation of hepatic LDL-R [LDL (low-density lipoprotein) receptor]. Intramolecular autocatalytic processing of the PCSK9 zymogen in the endoplasmic reticulum results in a tightly associated complex between the prodomain and the catalytic domain. Although the...
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