Article
Identification of elements that dictate the specificity of mitochondrial Hsp60 for its co-chaperonin.
PloS one - 1 Jan 2012
Parnas Avital, Nisemblat Shahar, Weiss Celeste, Levy-Rimler Galit, Pri-Or Amir, Zor Tsaffrir, Lund Peter A, Bross Peter, Azem Abdussalam
Abstract excerpt
Type I chaperonins (cpn60/Hsp60) are essential proteins that mediate the folding of proteins in bacteria, chloroplast and mitochondria. Despite the high sequence homology among chaperonins, the mitochondrial chaperonin system has developed unique properties that distinguish it from the widely-studied bacterial system (GroEL and GroES). The most relevant difference to this study is that mitochondrial chaperonins...
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