[The reversion of multidrug resistance in tumour cell line MCF-7/Adr by ribozyme].

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Article

[The reversion of multidrug resistance in tumour cell line MCF-7/Adr by ribozyme].

Zhonghua yi xue za zhi - 1 Jul 1997

Yuan Y, Zhang J, Zhou D

Abstract excerpt

OBJECTIVE: To construct a specific hammerhead ribozyme possessing catalytic activity that cleaves the mdr1 mRNA for reversing the resistant phenotype in tumour cell line. METHODS: A DNA sequence encoding the ribozyme gene was incorporated into a eukaryotic expression vector (pH beta Apr-1 neu) an...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Antibiotics, Antineoplastic
Breast Neoplasms
Doxorubicin
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Female
Genes, MDR
Humans
Phenotype
RNA, Catalytic
RNA, Messenger
Transfection
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9772447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9772447-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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