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Article

[The reversion of multidrug resistance in tumour cell line MCF-7/Adr by ribozyme].

Zhonghua yi xue za zhi - 1 Jul 1997

Yuan Y, Zhang J, Zhou D

Abstract excerpt

OBJECTIVE: To construct a specific hammerhead ribozyme possessing catalytic activity that cleaves the mdr1 mRNA for reversing the resistant phenotype in tumour cell line. METHODS: A DNA sequence encoding the ribozyme gene was incorporated into a eukaryotic expression vector (pH beta Apr-1 neu) and transfected into the human breast carcinoma cell line MCF-7/Adr, which is resistant to adriamycin and expresses the...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 9772447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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