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Article

[Targeted down-regulation of p53 gene expression by individual antisense RNA in vitro].

Zhonghua bing li xue za zhi = Chinese journal of pathology - 1 Aug 2007

Wang Ya-hong, Sun Yu-lan, Xu Shao-feng, Zhang Yuan-yuan, Zhang Lin, Zhang Bin, Feng Yu-mei, Niu Rui-fang, Fu Li

Abstract excerpt

OBJECTIVE: To investigate the effect of specific blockage of mutant p53 gene by individualized antisense RNA in vitro. METHODS: Mutation status of p53 in human breast cancer cell lines was determined by immunocytochemical staining, PCR-SSCP and sequencing. Single strand antisense transcription system targeting specific p53 mutation site (mt-p53) was constructed, and corresponding antisense RNA was prepared. The...

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Identifiers

PMID: 17980103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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