Article
mdr1 ribozyme mediated reversal of the multi-drug resistant phenotype in human lung cell lines.
Cytotechnology - 1 Jan 1996
Daly C, Coyle S, McBride S, O'Driscoll L, Daly N, Scanlon K, Clynes M
Abstract excerpt
An mdr1 hammerhead was introduced into two adriamycin-selected multi-drug resistant human lung cell lines both of which over-express p-glycoprotein. Expression of the ribozyme resulted in a decrease in mdr1 mRNA expression and an increase in drug sensitivity in both cell lines. This would suggest...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.