Article
Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 2.
FEBS letters - 25 Sept 1998
Qin L, Denda K, Shimomura T, Kawaguchi T, Kitamura N
Abstract excerpt
Hepatocyte growth factor activator inhibitor type 2 (HAI-2) was identified as a potent inhibitor of hepatocyte growth factor activator (HGF activator). The primary translation product of HAI-2 contains two Kunitz domains. To characterize their function, we introduced a point mutation into the reactive site of each Kunitz domain, and assayed the mutants for their HGF activator inhibitory activity. A point mutation...
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