Article
Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 2.
FEBS letters - 25 Sept 1998
Qin L, Denda K, Shimomura T, Kawaguchi T, Kitamura N
Abstract excerpt
Hepatocyte growth factor activator inhibitor type 2 (HAI-2) was identified as a potent inhibitor of hepatocyte growth factor activator (HGF activator). The primary translation product of HAI-2 contains two Kunitz domains. To characterize their function, we introduced a point mutation into the rea...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- CHO Cells
- Cricetinae
- DNA, Complementary
- Membrane Glycoproteins
- Molecular Sequence Data
- Mutation
- Recombinant Proteins
- Serine Endopeptidases
- Transfection
- Trypsin Inhibitor, Kunitz Soybean