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Article

Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1.

The Journal of biological chemistry - 19 Sept 2003

Kirchhofer Daniel, Peek Mark, Li Wei, Stamos Jennifer, Eigenbrot Charles, Kadkhodayan Saloumeh, Elliott J Michael, Corpuz Racquel T, Lazarus Robert A, Moran Paul

Abstract excerpt

Hepatocyte growth factor activator inhibitor-1 (HAI-1) is an integral membrane protein expressed on epithelial cells and contains two extracellular Kunitz domains (N-terminal KD1 and C-terminal KD2) known to inhibit trypsin-like serine proteases. In tumorigenesis and tissue regeneration, HAI-1 regulates the hepatocyte growth factor (HGF)/c-Met pathway by inhibiting the activity of HGF activator (HGFA) and...

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PMID: 12815039
DOI: 10.1074/jbc.M304643200

Genes

HGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1.PMID 12815039Read ↗

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