Article
p53 mutations in skin and internal tumors of xeroderma pigmentosum patients belonging to the complementation group C.
Cancer research - 1 Oct 1998
Giglia G, Dumaz N, Drougard C, Avril M F, Daya-Grosjean L, Sarasin A
Abstract excerpt
Fifty-eight skin biopsies and three primary internal tumors from patients affected by the rare hereditary disease xeroderma pigmentosum (XP) were studied by an improved PCR-single strand conformation polymorphism analysis to detect the mutations of the tumor suppressor gene p53. The results from...
Topics
- Adenocarcinoma
- Amino Acid Substitution
- Base Sequence
- Brain Neoplasms
- Child
- Child, Preschool
- DNA Repair
- DNA Replication
- Exons
- Genes, p53
- Genetic Complementation Test
- Glioma
- Humans
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Precancerous Conditions
- Skin Neoplasms