Article
p53 mutations in skin and internal tumors of xeroderma pigmentosum patients belonging to the complementation group C.
Cancer research - 1 Oct 1998
Giglia G, Dumaz N, Drougard C, Avril M F, Daya-Grosjean L, Sarasin A
Abstract excerpt
Fifty-eight skin biopsies and three primary internal tumors from patients affected by the rare hereditary disease xeroderma pigmentosum (XP) were studied by an improved PCR-single strand conformation polymorphism analysis to detect the mutations of the tumor suppressor gene p53. The results from cutaneous XP tumors, including 27 squamous cell carcinomas and 6 basal cell carcinomas, show a very high level (86%) of...
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