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Article

Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity.

The Journal of biological chemistry - 11 May 2012

Stankiewicz Trisha R, Loucks F Alexandra, Schroeder Emily K, Nevalainen Marja T, Tyler Kenneth L, Aktories Klaus, Bouchard Ron J, Linseman Daniel A

Abstract excerpt

In several neuronal cell types, the small GTPase Rac is essential for survival. We have shown previously that the Rho family GTPase inhibitor Clostridium difficile toxin B (ToxB) induces apoptosis in primary rat cerebellar granule neurons (CGNs) principally via inhibition of Rac GTPase function....

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Source

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Identifiers

PMID: 22378792
DOI: 10.1074/jbc.M111.302166
PMCID: PMC3351344

Genes

STAT3
STAT1
CGN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22378792-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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