Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apoptotic cells, including macrophages, are prominent in Theiler's virus-induced inflammatory, demyelinating lesions.

Journal of virology - 1 Apr 2003

Schlitt Brian P, Felrice Matthew, Jelachich Mary Lou, Lipton Howard L

Abstract excerpt

Theiler's murine encephalomyelitis virus (TMEV) persists in the mouse central nervous system principally in macrophages, and infected macrophages in culture undergo apoptosis. We have detected abundant apoptotic cells in perivascular cuffs and inflammatory, demyelinating lesions of SJL mice chronically infected with TMEV. T cells comprised 74% of apoptotic cells, while 8% were macrophages, 0.6% were astrocytes,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Demyelinating Diseases
Share to Genome, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to In Situ Hybridization

Share to Macrophages

Share to RNA, Viral

Share to Spinal Cord

Share to T-Lymphocytes

Share to Theilovirus

Source

Open in PubMed Open full text

Identifiers

PMID: 12634394
DOI: 10.1128/jvi.77.7.4383-4388.2003
PMCID: PMC150662

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apoptotic cells, including macrophages, are prominent in Theiler's virus-induced inflammatory, demyelinating lesions.PMID 12634394Read ↗

Transcriptomic Analysis Suggests the M1 Polarization and Launch of Diverse Programmed Cell Death Pathways in Japanese Encephalitis Virus-Infected MacrophagesSemantic proximity Read ↗

Microglia are more susceptible than macrophages to apoptosis in the central nervous system in experimental autoimmune encephalomyelitis through a mechanism not involving Fas (CD95).Semantic proximity Read ↗

CD8+ T cells specific for cryptic apoptosis-associated epitopes exacerbate experimental autoimmune encephalomyelitis.Semantic proximity Read ↗

Apoptotic CD8 T-lymphocytes disable macrophage-mediated immunity to Trypanosoma cruzi infection.Semantic proximity Read ↗

The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically?Semantic proximity Read ↗

Role of macrophages during Theiler's virus infection.Semantic proximity Read ↗

Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice.Semantic proximity Read ↗

Effect of Apoptotic Cell Recognition on Macrophage Polarization and Mycobacterial PersistenceSemantic proximity Read ↗

A protein critical for a Theiler's virus-induced immune system-mediated demyelinating disease has a cell type-specific antiapoptotic effect and a key role in virus persistence.Semantic proximity Read ↗

Inflammation is a component of neurodegeneration in response to Venezuelan equine encephalitis virus infection in mice.Semantic proximity Read ↗

Induction of Caspase-Dependent Apoptosis in Cultured Rat Oligodendrocytes by Murine Coronavirus Is Mediated during Cell Entry and Does Not Require Virus ReplicationSemantic proximity Read ↗

Degenerating processes identified by electron microscopic immunocytochemical methods.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.