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Article

Effects of mutations in the gamma-phosphate binding site of myosin on its motor function.

The Journal of biological chemistry - 16 Oct 1998

Li X D, Rhodes T E, Ikebe R, Kambara T, White H D, Ikebe M

Abstract excerpt

The role of the highly conserved residues in the gamma-phosphate binding site of myosin upon myosin motor function was studied. Each of five residues (Ser181, Lys185, Asn235, Ser236, and Arg238) in smooth muscle myosin was mutated. K185Q has neither a steady state ATPase nor an initial Pi burst. Although ATP and actin bind to K185Q, it is not dissociated from actin by ATP. These results indicate that the...

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PMID: 9765269
DOI: 10.1074/jbc.273.42.27404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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