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Article

Kinetic effects of kinesin switch I and switch II mutations.

The Journal of biological chemistry - 4 Nov 2005

Auerbach Scott D, Johnson Kenneth A

Abstract excerpt

We have examined several mutants in the switch I, switch II region of rat kinesin. Pre-steady-state kinetic analysis of association and dissociation of an N256K mutant with nucleotides and microtubules demonstrates that the mutation blocks microtubule stimulation of nucleotide release and ATP hydrolysis without affecting other kinetic parameters. The results suggest that ADP release on one head may be coupled to...

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Identifiers

PMID: 16118217
DOI: 10.1074/jbc.M502985200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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