Article
PTCH gene mutations in invasive transitional cell carcinoma of the bladder.
Oncogene - 3 Sept 1998
McGarvey T W, Maruta Y, Tomaszewski J E, Linnenbach A J, Malkowicz S B
Abstract excerpt
LOH analysis suggests that multiple tumor suppressor genes play a role in the development of human TCC. The human homolog of the Drosophila PTCH was recently cloned and mapped to the BCNS locus on 9q22.3, a chromosomal region commonly deleted in TCCs. We first examined the steady state mRNA trans...
Topics
- Carcinoma, Transitional Cell
- DNA Mutational Analysis
- DNA-Binding Proteins
- Drosophila Proteins
- Gene Expression
- Genes
- Humans
- Kruppel-Like Transcription Factors
- Membrane Proteins
- Mutation
- Nerve Tissue Proteins
- Patched Receptors
- Patched-1 Receptor
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Receptors, Cell Surface
- Receptors, G-Protein-Coupled
- Repressor Proteins