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Article

PTCH gene mutations in invasive transitional cell carcinoma of the bladder.

Oncogene - 3 Sept 1998

McGarvey T W, Maruta Y, Tomaszewski J E, Linnenbach A J, Malkowicz S B

Abstract excerpt

LOH analysis suggests that multiple tumor suppressor genes play a role in the development of human TCC. The human homolog of the Drosophila PTCH was recently cloned and mapped to the BCNS locus on 9q22.3, a chromosomal region commonly deleted in TCCs. We first examined the steady state mRNA transcription of the PTCH, SMOH and GLI3 genes of the HH signal transduction pathway in TCC cell lines and normal...

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Source

Identifiers

PMID: 9764827
DOI: 10.1038/sj.onc.1202045

Genes

GLI3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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PTCH gene mutations in invasive transitional cell carcinoma of the bladder.PMID 9764827Read ↗

Identification of novel bladder tumour suppressor genes.Semantic proximity Read ↗

A novel mutation of the PTCH1 gene activates the Shh/Gli signaling pathway in a Chinese family with nevoid basal cell carcinoma syndrome.Semantic proximity Read ↗

Human bladder tumors with 2-hit mutations of tumor suppressor gene TSC1 and decreased expression of p27.Semantic proximity Read ↗

Papillary urothelial hyperplasia is a clonal precursor to papillary transitional cell bladder cancerSemantic proximity Read ↗

Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations.Semantic proximity Read ↗

Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.Semantic proximity Read ↗

A missense mutation in <i>PTCH2</i> underlies dominantly inherited NBCCS in a Chinese familySemantic proximity Read ↗

Mutation spectrum of the 9q34 tuberous sclerosis gene TSC1 in transitional cell carcinoma of the bladder.Semantic proximity Read ↗

Analysis of the PTCH1 signaling pathway in ovarian dermoids.Semantic proximity Read ↗

Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site.Semantic proximity Read ↗

Evidence for two candidate tumour suppressor loci on chromosome 9q in transitional cell carcinoma (TCC) of the bladder but no homozygous deletions in bladder tumour cell lines.Semantic proximity Read ↗

PTCH1 mutation is a frequent event in oesophageal basaloid squamous cell carcinoma.Semantic proximity Read ↗

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