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Article

PTCH1 mutation is a frequent event in oesophageal basaloid squamous cell carcinoma.

Mutagenesis - 1 Mar 2015

Saito Tsuyoshi, Mitomi Hiroyuki, Imamhasan Abdukadir, Hayashi Takuo, Kurisaki-Arakawa Aiko, Mitani Keiko, Takahashi Michiko, Kajiyama Yoshiaki, Yao Takashi

Abstract excerpt

Basaloid squamous cell carcinoma (BSCC) is a rare and poorly differentiated variant of typical squamous cell carcinoma, and is characterised in part by activation of the Wnt signalling pathway. We previously demonstrated that constitutive activation of the Wnt signalling pathway by epigenetic silencing of secreted frizzled-related protein 4 (SFRP4) is observed in this tumour. Increasing evidence shows that the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25395299
DOI: 10.1093/mutage/geu072

Genes

PTCH1
APC
SFRP4
SFRP5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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