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Article

Human bladder tumors with 2-hit mutations of tumor suppressor gene TSC1 and decreased expression of p27.

The Journal of urology - 1 Aug 2003

Adachi Hiroyuki, Igawa Mikio, Shiina Hiroaki, Urakami Shinji, Shigeno Kazushi, Hino Okio

Abstract excerpt

PURPOSE: Because loss of chromosome 9 is known to be the most common finding in human bladder tumors, we studied the mutation of the tumor suppressor gene TSC1 (chromosome 9q34) in bladder tumors. Since another tumor suppressor gene, TSC2 (chromosome 16p13.3), is reported to interact with TSC1 in the pathway that modulates tumor suppression, we assessed loss of heterozygosity (LOH) at 16p13.3. Furthermore, we...

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Share to Carcinoma, Transitional Cell
Share to Cyclin-Dependent Kinase Inhibitor p27

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Tumor Suppressor

Share to Loss of Heterozygosity

Share to Tuberous Sclerosis Complex 1 Protein

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Share to Urinary Bladder Neoplasms

Source

Identifiers

PMID: 12853839
DOI: 10.1097/01.ju.0000074621.74361.10

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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