Overexpression of fra-2 in transgenic mice perturbs normal eye development.

doi:10.1038/sj.onc.1202044

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Article

Overexpression of fra-2 in transgenic mice perturbs normal eye development.

Oncogene - 3 Sept 1998

McHenry J Z, Leon A, Matthaei K I, Cohen D R

Abstract excerpt

The major components of transcription factor AP-1 (Activator Protein 1) are encoded by the two families of genes related to the proto-oncogenes c-fos and c-jun. The fos-related antigen-2 (fra-2) gene is the most recently described member of the Fos family. To determine the oncogenic potential of...

Topics

3T3 Cells
Animals
Body Constitution
DNA-Binding Proteins
Eye
Eye Abnormalities
Fos-Related Antigen-2
Gene Expression Regulation, Developmental
Histocytochemistry
Mice
Mice, Transgenic
Phenotype
Promoter Regions, Genetic
Transcription Factors
Transforming Growth Factor alpha
Transgenes

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