Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of fra-2 in transgenic mice perturbs normal eye development.

Oncogene - 3 Sept 1998

McHenry J Z, Leon A, Matthaei K I, Cohen D R

Abstract excerpt

The major components of transcription factor AP-1 (Activator Protein 1) are encoded by the two families of genes related to the proto-oncogenes c-fos and c-jun. The fos-related antigen-2 (fra-2) gene is the most recently described member of the Fos family. To determine the oncogenic potential of fra-2, transgenic mice were generated which over-express fra-2 in a number of tissues. No tumours were evident in any...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to DNA-Binding Proteins
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Phenotype

Share to Promoter Regions, Genetic

Share to Transcription Factors

Source

Identifiers

PMID: 9764823
DOI: 10.1038/sj.onc.1202044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of fra-2 in transgenic mice perturbs normal eye development.PMID 9764823Read ↗

Lens expression of TGF alpha in transgenic mice produces two distinct eye pathologies in the absence of tumors.Semantic proximity Read ↗

Disregulation of ocular morphogenesis by lens-specific expression of FGF-3/int-2 in transgenic mice.Semantic proximity Read ↗

Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice.Semantic proximity Read ↗

Generation of a new mouse model of glaucoma characterized by reduced expression of the AP-2β and AP-2δ proteins.Semantic proximity Read ↗

Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1Semantic proximity Read ↗

Expression of a truncated FGF receptor results in defective lens development in transgenic mice.Semantic proximity Read ↗

Tissue-specific transgenic knockdown of Fos-related antigen 2 (Fra-2) expression mediated by dominant negative Fra-2.Semantic proximity Read ↗

TGF alpha can act as a chemoattractant to perioptic mesenchymal cells in developing mouse eyes.Semantic proximity Read ↗

TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice.Semantic proximity Read ↗

Activated Ras induces lens epithelial cell hyperplasia but not premature differentiation.Semantic proximity Read ↗

High levels of phosphorylated c-Jun, Fra-1, Fra-2 and ATF-2 proteins correlate with malignant phenotypes in the multistage mouse skin carcinogenesis model.Semantic proximity Read ↗

Bcl-2 and Bax regulation of corneal homeostasis in genetically altered mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.