The relationship between thiopurine methyltransferase activity and genotype in blasts from patients with acute leukemia.

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Article

The relationship between thiopurine methyltransferase activity and genotype in blasts from patients with acute leukemia.

Blood - 15 Oct 1998

Coulthard S A, Howell C, Robson J, Hall A G

Abstract excerpt

The level of expression of the enzyme thiopurine methyltransferase (TPMT) is an important determinant of the metabolism of thiopurines used in the treatment of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Studies in red blood cells (RBC) have shown that TPMT expression dis...

Topics

Acute Disease
Adolescent
Adult
Aged
Antimetabolites, Antineoplastic
Child
Child, Preschool
Drug Resistance, Neoplasm
Enzyme Induction
Female
Genotype
Humans
Hypoxanthine Phosphoribosyltransferase
Infant
Leukemia
Male
Mercaptopurine
Methyltransferases

Source

Open in PubMed

Identifiers

PMID: 9763570

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9763570-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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